Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.

Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.

There is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethally irradiated mice. A single administration of YH25...

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Main Authors: Yi Zhao, Kaijin Wu, Cu Nguyen, Goar Smbatyan, Elisabeth Melendez, Yusuke Higuchi, Yibu Chen, Michael Kahn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5423697?pdf=render
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spelling doaj-0c836b93e6c44cbeb1d412dbcec4d3f82020-11-25T00:48:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017724510.1371/journal.pone.0177245Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.Yi ZhaoKaijin WuCu NguyenGoar SmbatyanElisabeth MelendezYusuke HiguchiYibu ChenMichael KahnThere is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethally irradiated mice. A single administration of YH250 24 hours post irradiation can significantly stimulate HSC proliferation, improve survival and accelerate peripheral blood count recovery. Our studies suggest that promotion of the expansion of the remaining HSC population via stimulation of symmetric non-differentiative proliferation is at least part of the mechanism of action.http://europepmc.org/articles/PMC5423697?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Yi Zhao
Kaijin Wu
Cu Nguyen
Goar Smbatyan
Elisabeth Melendez
Yusuke Higuchi
Yibu Chen
Michael Kahn
spellingShingle Yi Zhao
Kaijin Wu
Cu Nguyen
Goar Smbatyan
Elisabeth Melendez
Yusuke Higuchi
Yibu Chen
Michael Kahn
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
PLoS ONE
author_facet Yi Zhao
Kaijin Wu
Cu Nguyen
Goar Smbatyan
Elisabeth Melendez
Yusuke Higuchi
Yibu Chen
Michael Kahn
author_sort Yi Zhao
title Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
title_short Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
title_full Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
title_fullStr Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
title_full_unstemmed Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
title_sort small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description There is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethally irradiated mice. A single administration of YH250 24 hours post irradiation can significantly stimulate HSC proliferation, improve survival and accelerate peripheral blood count recovery. Our studies suggest that promotion of the expansion of the remaining HSC population via stimulation of symmetric non-differentiative proliferation is at least part of the mechanism of action.
url http://europepmc.org/articles/PMC5423697?pdf=render
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AT kaijinwu smallmoleculep300cateninantagonistenhanceshematopoieticrecoveryafterradiation
AT cunguyen smallmoleculep300cateninantagonistenhanceshematopoieticrecoveryafterradiation
AT goarsmbatyan smallmoleculep300cateninantagonistenhanceshematopoieticrecoveryafterradiation
AT elisabethmelendez smallmoleculep300cateninantagonistenhanceshematopoieticrecoveryafterradiation
AT yusukehiguchi smallmoleculep300cateninantagonistenhanceshematopoieticrecoveryafterradiation
AT yibuchen smallmoleculep300cateninantagonistenhanceshematopoieticrecoveryafterradiation
AT michaelkahn smallmoleculep300cateninantagonistenhanceshematopoieticrecoveryafterradiation
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