Establishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters

Establishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters

Abstract Background 2-Keto-l-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, l-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicigenium vulgare and Bacillus megaterium. Due to the different nutrient...

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Bibliographic Details
Main Authors: Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu, Yi-Xuan Zhang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Microbial Cell Factories
Subjects:
Ketogulonicigenium
Metabolic pathway
Genome analysis
Promoter
Phosphoketolase
Phosphotransacetylase
Online Access:http://link.springer.com/article/10.1186/s12934-018-0932-9

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