Impact of Surface Properties of Core Material on the Stability of Hot Melt-Coated Multiparticulate Systems

Impact of Surface Properties of Core Material on the Stability of Hot Melt-Coated Multiparticulate Systems

Hot melt coating (HMC) of an active pharmaceutical ingredient (API) powder with lipid-based excipients is an innovative method for manufacturing patient-convenient dosage forms. However, drug release instability is still its main industrial challenge. The correlation between the unstable pharmaceuti...

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Bibliographic Details
Main Authors:	Sonja Schertel, Sharareh Salar-Behzadi, Andreas Zimmer
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Pharmaceutics
Subjects:	hot melt coating lipid-based formulation product instability surface energy characteristics crystal growth phase separation
Online Access:	https://www.mdpi.com/1999-4923/13/3/366

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