Study of Indicators for Early and Rapid Diagnosis of Radiation Injury Is the Most Important in Patients With Cancer During Radiotherapy

• Main Authors: Gang Liu, Li-Mei Niu, Li-Qin Wang, Ye Li, Xiao-Qin Wu, Yin-Yin Liu, Rong Zhang
• Format: Article
• Language: English
• Published: SAGE Publishing 2020-03-01
• Series: Dose-Response
• Online Access: https://doi.org/10.1177/1559325820913360

Objective: To establish a complete technical solution for the radiation biological dose estimation, to enable prediction of individuals’ response to radiotherapy (RT), and to control treatment dose for reduced irradiation injury and promote repair; and to evaluate the risk of radiation-induced late effects for patients undergoing external photon beam RT and provide the reliable dose–response relationships. Methods: Select 49 tumor patients using 60 Co and linear accelerator for radiation therapy; initial radiation dose was 250 cGy. Chromosome aberration and blood count were analyzed before radiation therapy and 2 hours after the first day of RT. Results: Two hours after the first day of RT, peripheral blood cell count of lymphocytes of patients with cancer was significantly decreased ( P < .01). The frequency of chromosome aberration was higher ( P < .01). Conclusion: High-dose radiation of the radiation therapy makes significant injuries to peripheral blood lymphocytes.