Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer’s disease models

Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer’s disease models

Abstract Alzheimer’s disease (AD) is characterized by aberrant accumulation of extracellular β-amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most neurotoxic species and are correlated with cognitive dysfunction in early AD. However, there is still no effective treatm...

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Bibliographic Details
Main Authors: Xiu Yang, Xu Li, Le Liu, Yuan-Hao Chen, Yue You, Yin Gao, Yue-Ying Liu, Li Yang, Kun Tong, Di-Shi Chen, Jing-Ru Hao, Nan Sun, Zi-Ming Zhao, Can Gao
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00639-1

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