A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis

A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis

For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, neces...

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Main Authors: Haruka Momose, Takuo Mizukami, Masaki Ochiai, Isao Hamaguchi, Kazunari Yamaguchi
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2010/361841
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spelling doaj-0c637f86b6e04476876829491a98a7222020-11-24T21:24:18ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/361841361841A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression AnalysisHaruka Momose0Takuo Mizukami1Masaki Ochiai2Isao Hamaguchi3Kazunari Yamaguchi4Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, JapanDepartment of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, JapanDivision of Quality Assurance, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, JapanDepartment of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, JapanDepartment of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, JapanFor the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity.http://dx.doi.org/10.1155/2010/361841
collection DOAJ
language English
format Article
sources DOAJ
author Haruka Momose
Takuo Mizukami
Masaki Ochiai
Isao Hamaguchi
Kazunari Yamaguchi
spellingShingle Haruka Momose
Takuo Mizukami
Masaki Ochiai
Isao Hamaguchi
Kazunari Yamaguchi
A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
Journal of Biomedicine and Biotechnology
author_facet Haruka Momose
Takuo Mizukami
Masaki Ochiai
Isao Hamaguchi
Kazunari Yamaguchi
author_sort Haruka Momose
title A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_short A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_full A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_fullStr A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_full_unstemmed A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
title_sort new method for the evaluation of vaccine safety based on comprehensive gene expression analysis
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2010-01-01
description For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity.
url http://dx.doi.org/10.1155/2010/361841
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