NEAr Transporter (NEAT) Domains: Unique Surface Displayed Heme Chaperones That Enable Gram-Positive Bacteria to Capture Heme-Iron From Hemoglobin

NEAr Transporter (NEAT) Domains: Unique Surface Displayed Heme Chaperones That Enable Gram-Positive Bacteria to Capture Heme-Iron From Hemoglobin

Iron is an important micronutrient that is required by bacteria to proliferate and to cause disease. Many bacterial pathogens forage iron from human hemoglobin (Hb) during infections, which contains this metal within heme (iron–protoporphyrin IX). Several clinically important pathogenic species with...

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Bibliographic Details
Main Authors: Ken Ellis-Guardiola, Brendan J. Mahoney, Robert T. Clubb
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
Staphylococcus aureus
heme
hemoglobin
NEAr transporter domains
sortase
iron regulated surface determinant system
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.607679/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.607679/full

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