Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin

Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin

<p>Abstract</p> <p>Background</p> <p>Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential st...

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Bibliographic Details
Main Authors: Calkins Anne S, Sobhian Bijan, Adelmant Guillaume, Sand-Dejmek Janna, Marto Jarrod, Iglehart Dirk J, Lazaro Jean-Bernard
Format: Article
Language:English
Published: BMC 2011-06-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/10/1/74

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