Deep sequencing of HIV-1 variants from paired plasma and cerebrospinal fluid during primary HIV infection

Deep sequencing of HIV-1 variants from paired plasma and cerebrospinal fluid during primary HIV infection

Background: Limited data exist comparing viral quasispecies between cerebrospinal fluid (CSF) and plasma compartments during primary HIV infection. Deep sequencing is a new method to examine the HIV plasma and CSF quasispecies. Methods: In this pilot study, deep sequencing of protease (PR) and rever...

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Bibliographic Details
Main Authors: Arjet Gega, Michael J. Kozal, Jennifer Chiarella, Evelyn Lee, Julia Peterson, Frederick M. Hecht, Teri Liegler, Elizabeth P. St John, Birgitte B. Simen, Richard W. Price, Serena S. Spudich
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Virus Eradication
Subjects:
HIV-1
resistance mutations
cerebrospinal fluid
compartmentalisation
HIV-associated neurocognitive disorder
primary HIV infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664020309262

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