Decreased STAT3 Phosphorylation Mediates Cell Swelling in Ammonia-Treated Astrocyte Cultures

Decreased STAT3 Phosphorylation Mediates Cell Swelling in Ammonia-Treated Astrocyte Cultures

Brain edema, due largely to astrocyte swelling, and the subsequent increase in intracranial pressure and brain herniation, are major complications of acute liver failure (ALF). Elevated level of brain ammonia has been strongly implicated in the development of astrocyte swelling associated with ALF....

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Bibliographic Details
Main Authors: Arumugam R. Jayakumar, Kevin M. Curtis, Kiran S. Panickar, Nagarajarao Shamaladevi, Michael D. Norenberg
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Biology
Subjects:
acute liver failure
ammonia
astrocyte swelling
STAT3 dephosphorylation
protein tyrosine phosphatase receptor type-1
Online Access:http://www.mdpi.com/2079-7737/5/4/48

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http://www.mdpi.com/2079-7737/5/4/48

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