Diagnostic and Prognostic Role of Blood and Cerebrospinal Fluid and Blood Neurofilaments in Amyotrophic Lateral Sclerosis: A Review of the Literature

Diagnostic and Prognostic Role of Blood and Cerebrospinal Fluid and Blood Neurofilaments in Amyotrophic Lateral Sclerosis: A Review of the Literature

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting upper and lower motor neurons (MNs) that still lacks an efficacious therapy. The failure of recent therapeutic trials in ALS, other than depending on the poor knowledge of pathogenic mechanisms responsible for MNs lo...

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Bibliographic Details
Main Authors: Delia Gagliardi, Megi Meneri, Domenica Saccomanno, Nereo Bresolin, Giacomo Pietro Comi, Stefania Corti
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
neurofilaments
p-NfH
NfL
cerebrospinal fluid
blood
biomarkers
Online Access:https://www.mdpi.com/1422-0067/20/17/4152

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