Cardiac Differentiation of Adipose Tissue-Derived Stem Cells Is Driven by BMP4 and bFGF but Counteracted by 5-Azacytidine and Valproic Acid

Cardiac Differentiation of Adipose Tissue-Derived Stem Cells Is Driven by BMP4 and bFGF but Counteracted by 5-Azacytidine and Valproic Acid

Objective: Bone morphogenetic protein 4 (BMP4) and basic fibroblast growth factor (bFGF) play important roles in embryonic heart development. Also, two epigenetic modifying molecules, 5ˊ-azacytidine (5ˊ-Aza) and valproic acid (VPA) induce cardiomyogenesis in the infarcted heart. In this study, we...

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Bibliographic Details
Main Authors: Sanaz Hasani, Arash Javeri, Asadollah Asadi, Masoumeh Fakhr Taha
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2020-10-01
Series:Cell Journal
Subjects:
adipose tissue-derived stem cells
basic fibroblast growth factor
bmp4
cardiomyocyte
small molecules
Online Access:https://celljournal.org/journal/article/abstract/6582

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