Synthesis, anti-angiogenic and DNA cleavage studies of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives

Synthesis, anti-angiogenic and DNA cleavage studies of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives

Abstract A series of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives 10(a–f), 12(a–c) and 14(a–c) were synthesized and characterized by FTIR, 1H-NMR, mass spectral and elemental analysis. The efficacy of these derivatives to inhibit in vivo angi...

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Bibliographic Details
Main Authors: Vinaya Kambappa, G. K. Chandrashekara, N. D. Rekha, Prasanna D. Shivaramu, Komaraiah Palle
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Chemistry Central Journal
Subjects:
Pyrimidine
3-acetylpyridine
N-methyl morpholine
Antiangiogenic activity
CAM assay
DNA cleavage activity
Online Access:http://link.springer.com/article/10.1186/s13065-017-0354-5

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http://link.springer.com/article/10.1186/s13065-017-0354-5

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