Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits

Molecular mechanisms controlling axonal growth cone behaviour are only partially understood. Here the authors reveal a role of an adaptor protein GIPC1 in Plexin-D1 receptor recycling, and show that this process is required for axon track formation and vascular patterning in mice.

Bibliographic Details
Main Authors:	Katja Burk, Erik Mire, Anaïs Bellon, Mélanie Hocine, Jeremy Guillot, Filipa Moraes, Yutaka Yoshida, Michael Simons, Sophie Chauvet, Fanny Mann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14508

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spelling	doaj-0c33279192a44b8494aa04a9da0571f52021-05-11T07:20:40ZengNature Publishing GroupNature Communications2041-17232017-02-018111710.1038/ncomms14508Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuitsKatja Burk0Erik Mire1Anaïs Bellon2Mélanie Hocine3Jeremy Guillot4Filipa Moraes5Yutaka Yoshida6Michael Simons7Sophie Chauvet8Fanny Mann9Aix Marseille Univ, CNRS, IBDMAix Marseille Univ, CNRS, IBDMAix Marseille Univ, CNRS, IBDMAix Marseille Univ, CNRS, IBDMAix Marseille Univ, CNRS, IBDMDepartment of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale University School of MedicineDivision of Developmental Biology, Cincinnati Children’s Hospital Medical CenterDepartment of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale University School of MedicineAix Marseille Univ, CNRS, IBDMAix Marseille Univ, CNRS, IBDMMolecular mechanisms controlling axonal growth cone behaviour are only partially understood. Here the authors reveal a role of an adaptor protein GIPC1 in Plexin-D1 receptor recycling, and show that this process is required for axon track formation and vascular patterning in mice.https://doi.org/10.1038/ncomms14508
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Katja Burk Erik Mire Anaïs Bellon Mélanie Hocine Jeremy Guillot Filipa Moraes Yutaka Yoshida Michael Simons Sophie Chauvet Fanny Mann
spellingShingle	Katja Burk Erik Mire Anaïs Bellon Mélanie Hocine Jeremy Guillot Filipa Moraes Yutaka Yoshida Michael Simons Sophie Chauvet Fanny Mann Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits Nature Communications
author_facet	Katja Burk Erik Mire Anaïs Bellon Mélanie Hocine Jeremy Guillot Filipa Moraes Yutaka Yoshida Michael Simons Sophie Chauvet Fanny Mann
author_sort	Katja Burk
title	Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits
title_short	Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits
title_full	Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits
title_fullStr	Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits
title_full_unstemmed	Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits
title_sort	post-endocytic sorting of plexin-d1 controls signal transduction and development of axonal and vascular circuits
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-02-01
description	Molecular mechanisms controlling axonal growth cone behaviour are only partially understood. Here the authors reveal a role of an adaptor protein GIPC1 in Plexin-D1 receptor recycling, and show that this process is required for axon track formation and vascular patterning in mice.
url	https://doi.org/10.1038/ncomms14508
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Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits

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