Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia

Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia

We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with tolui...

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Main Authors: Alicia Rojas-Atencio, Karelis Urdaneta, Marisol Soto-Quintana, Francisco Alvarez Nava, Jenny Cañizales, Ernesto Solis
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Case Reports in Pathology
Online Access:http://dx.doi.org/10.1155/2011/269491
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spelling doaj-0c1f92c77bbb4b0b904d0da7b14d444c2020-11-25T00:03:46ZengHindawi LimitedCase Reports in Pathology2090-67812090-679X2011-01-01201110.1155/2011/269491269491Trisomy 19 and T(9;22) In a Patient with Acute Basophilic LeukemiaAlicia Rojas-Atencio0Karelis Urdaneta1Marisol Soto-Quintana2Francisco Alvarez Nava3Jenny Cañizales4Ernesto Solis5Genetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaWe report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22).http://dx.doi.org/10.1155/2011/269491
collection DOAJ
language English
format Article
sources DOAJ
author Alicia Rojas-Atencio
Karelis Urdaneta
Marisol Soto-Quintana
Francisco Alvarez Nava
Jenny Cañizales
Ernesto Solis
spellingShingle Alicia Rojas-Atencio
Karelis Urdaneta
Marisol Soto-Quintana
Francisco Alvarez Nava
Jenny Cañizales
Ernesto Solis
Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
Case Reports in Pathology
author_facet Alicia Rojas-Atencio
Karelis Urdaneta
Marisol Soto-Quintana
Francisco Alvarez Nava
Jenny Cañizales
Ernesto Solis
author_sort Alicia Rojas-Atencio
title Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_short Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_full Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_fullStr Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_full_unstemmed Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_sort trisomy 19 and t(9;22) in a patient with acute basophilic leukemia
publisher Hindawi Limited
series Case Reports in Pathology
issn 2090-6781
2090-679X
publishDate 2011-01-01
description We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22).
url http://dx.doi.org/10.1155/2011/269491
work_keys_str_mv AT aliciarojasatencio trisomy19andt922inapatientwithacutebasophilicleukemia
AT karelisurdaneta trisomy19andt922inapatientwithacutebasophilicleukemia
AT marisolsotoquintana trisomy19andt922inapatientwithacutebasophilicleukemia
AT franciscoalvareznava trisomy19andt922inapatientwithacutebasophilicleukemia
AT jennycanizales trisomy19andt922inapatientwithacutebasophilicleukemia
AT ernestosolis trisomy19andt922inapatientwithacutebasophilicleukemia
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