Hydrogen Bonding: Between Strengthening the Crystal Packing and Improving Solubility of Three Haloperidol Derivatives

Hydrogen Bonding: Between Strengthening the Crystal Packing and Improving Solubility of Three Haloperidol Derivatives

The purpose of this study is to confirm the impact of polar functional groups on inter and intra-molecular hydrogen bonding in haloperidol (HP) and droperidol (DP) and, hence, their effects on dissolution using a new approach. To confirm our theory, a new molecule: deshydroxy-haloperidol (DHP) was d...

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Bibliographic Details
Main Authors: Hardeep Saluja, Ahmed Mehanna, Riccardo Panicucci, Eman Atef
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
drug crystal packing
hydrogen bonding
solid dispersion
haloperidol-related compounds
molecular interaction
hydrophobic interaction
droperidol
deshydroxyhaloperidol
Online Access:http://www.mdpi.com/1420-3049/21/6/719

Internet

http://www.mdpi.com/1420-3049/21/6/719

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