Development of T Lymphocytes in the Nasal-associated Lymphoid Tissue (NALT) from Growing Wistar Rats
The aim of the present report was to study the development of several T-lymphocyte subsets in the nasal-associated lymphoid tissue (NALT) of growing Wistar rats. CD5+ and CD4+ lymphocytes gradually increa...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2004-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/10446670410001670463 |
| Summary: | The aim of the present report was to study the development of
several T-lymphocyte subsets in the nasal-associated lymphoid
tissue (NALT) of growing Wistar rats. CD5+ and CD4+ lymphocytes
gradually increased with age. A predominance of CD8α+ over CD4+ T
cells was found from 7 to 45 days but from 45 to 60 days of age
T helper cells outnumbered the cytotoxic subpopulation. The majority
of CD8+ T lymphocytes expressed the heterodimeric isoform. The
most relevant findings by immunohistochemistry are: (1) the
predominance of TCRγδ+ and CD8α+ cells at 7 days postpartum over
all the other T-cell subpopulations; and (2) that TCRγβ+ outnumbered
TCRαβ+ T cells from 7 to 45 days postpartum whereas αβ T cells
predominated in 45- and 60-day-old rats. Besides, cytometric studies
have shown that the percentages of TCRγ+, CD8+, as well as the
population coexpressing both phenotypes (TCRγδ+CD8α+), were
significantly higher in rats at 7 days postpartum when compared to
60 day-old rats. In the present study, the finding of a high number
of γδ+ and CD8+ T cells early in NALT development may indicate the
importance of these subpopulations in the protection of the nasal
mucosa in suckling and weaning Wistar rats. |
|---|---|
| ISSN: | 1740-2522 1740-2530 |