Aggresome formation is regulated by RanBPM through an interaction with HDAC6

Aggresome formation is regulated by RanBPM through an interaction with HDAC6

In conditions of proteasomal impairment, the build-up of damaged or misfolded proteins activates a cellular response leading to the recruitment of damaged proteins into perinuclear aggregates called aggresomes. Aggresome formation involves the retrograde transport of cargo proteins along the microtu...

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Bibliographic Details
Main Authors: Louisa M. Salemi, Ahmad W. Almawi, Karen J. Lefebvre, Caroline Schild-Poulter
Format: Article
Language:English
Published: The Company of Biologists 2014-05-01
Series:Biology Open
Subjects:
Aggresome
RanBPM
HDAC6
Proteasome inhibition
DNA damage
Online Access:http://bio.biologists.org/content/3/6/418

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