IL-33 at the Crossroads of Metabolic Disorders and Immunity
As a cytokine in interleukin-1(IL-1) family, interleukin-33(IL-33) usually exists in the cytoplasm and cell nucleus. When the cells are activated or damaged, IL-33 can be secreted into extracellular and regulate the functions of various immune cells through binding to its specific receptor suppressi...
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doaj-0c026048e4144a7091f354ed927b652e2020-11-24T21:56:36ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-01-011010.3389/fendo.2019.00026432379IL-33 at the Crossroads of Metabolic Disorders and ImmunityLei Tu0Lijing Yang1Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, ChinaAs a cytokine in interleukin-1(IL-1) family, interleukin-33(IL-33) usually exists in the cytoplasm and cell nucleus. When the cells are activated or damaged, IL-33 can be secreted into extracellular and regulate the functions of various immune cells through binding to its specific receptor suppression of tumorigenicity 2 (ST2). Except regulating the function of immune cells including T cells, B cells, dendritic cells (DCs), macrophages, mast cells, and innate lymphoid cells, IL-33 also plays an important role in metabolic diseases and has received an increasing attention. This review summarizes the regulation of IL-33 on different immune cells in lipid metabolism, which will help to understand the pathology of abnormal lipid metabolic diseases, such as atherosclerosis and type 2 diabetes.https://www.frontiersin.org/article/10.3389/fendo.2019.00026/fullIL-33metabolismdiabetesinnate & adaptive immune responseST2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Tu Lijing Yang |
spellingShingle |
Lei Tu Lijing Yang IL-33 at the Crossroads of Metabolic Disorders and Immunity Frontiers in Endocrinology IL-33 metabolism diabetes innate & adaptive immune response ST2 |
author_facet |
Lei Tu Lijing Yang |
author_sort |
Lei Tu |
title |
IL-33 at the Crossroads of Metabolic Disorders and Immunity |
title_short |
IL-33 at the Crossroads of Metabolic Disorders and Immunity |
title_full |
IL-33 at the Crossroads of Metabolic Disorders and Immunity |
title_fullStr |
IL-33 at the Crossroads of Metabolic Disorders and Immunity |
title_full_unstemmed |
IL-33 at the Crossroads of Metabolic Disorders and Immunity |
title_sort |
il-33 at the crossroads of metabolic disorders and immunity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2019-01-01 |
description |
As a cytokine in interleukin-1(IL-1) family, interleukin-33(IL-33) usually exists in the cytoplasm and cell nucleus. When the cells are activated or damaged, IL-33 can be secreted into extracellular and regulate the functions of various immune cells through binding to its specific receptor suppression of tumorigenicity 2 (ST2). Except regulating the function of immune cells including T cells, B cells, dendritic cells (DCs), macrophages, mast cells, and innate lymphoid cells, IL-33 also plays an important role in metabolic diseases and has received an increasing attention. This review summarizes the regulation of IL-33 on different immune cells in lipid metabolism, which will help to understand the pathology of abnormal lipid metabolic diseases, such as atherosclerosis and type 2 diabetes. |
topic |
IL-33 metabolism diabetes innate & adaptive immune response ST2 |
url |
https://www.frontiersin.org/article/10.3389/fendo.2019.00026/full |
work_keys_str_mv |
AT leitu il33atthecrossroadsofmetabolicdisordersandimmunity AT lijingyang il33atthecrossroadsofmetabolicdisordersandimmunity |
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1725858149665079296 |