Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model

Proteotoxicity of misfolded, disease-causing proteins is deeply implicated in the pathomechanisms for neurodegenerative diseases including copper-zinc superoxide dismutase (SOD1)-linked amyotrophic lateral sclerosis (ALS). However, the precise cellular quality control (QC) mechanisms against aggrega...

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Bibliographic Details
Main Authors: Deepak Chhangani, Fumito Endo, Ayeman Amanullah, Arun Upadhyay, Seiji Watanabe, Ribhav Mishra, Koji Yamanaka, Amit Mishra
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
MGRN1
Cytotoxicity
Protein aggregation
SOD1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300942

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