Gene target selection for loop-mediated isothermal amplification for rapid discrimination of Treponema pallidum subspecies.

Gene target selection for loop-mediated isothermal amplification for rapid discrimination of Treponema pallidum subspecies.

We show proof of concept for gene targets (polA, tprL, and TP_0619) that can be used in loop-mediated isothermal amplification (LAMP) assays to rapidly differentiate infection with any of the three Treponema pallidum subspecies (pallidum (TPA), pertenue (TPE), and endemicum (TEN)) and which are know...

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Bibliographic Details
Main Authors: Sascha Knauf, Simone Lüert, David Šmajs, Michal Strouhal, Idrissa S Chuma, Sieghard Frischmann, Mohammed Bakheit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5978989?pdf=render

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