Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion

Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion

There has been an increasing use of hormonal therapy among male-to-female (MtF) transgender individuals. This long-term hormone replacement therapy (HRT) renders MtF individuals a unique patient subgroup in terms of breast cancer risk. This case describes a MtF transgender who presented with a breas...

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Main Authors: Krystina Tongson, Victoria Konovalova, Naveen Dhawan, Steffi Sharma, Jaya Bahl, Mohammad Masri
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2017/5172072
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spelling doaj-0bfc1728662a4dbfbb27ef4d5c71876a2020-11-24T23:25:27ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/51720725172072Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare LesionKrystina Tongson0Victoria Konovalova1Naveen Dhawan2Steffi Sharma3Jaya Bahl4Mohammad Masri5Department of General Surgery, Larkin Community Hospital, South Miami, FL, USADepartment of General Surgery, Larkin Community Hospital, South Miami, FL, USADivision of Health Sciences, Nova Southeastern University, Davie, FL, USAKasturba Medical College, Manipal, IndiaFlorida International University (FIU), Miami, FL, USADepartment of General Surgery, Larkin Community Hospital, South Miami, FL, USAThere has been an increasing use of hormonal therapy among male-to-female (MtF) transgender individuals. This long-term hormone replacement therapy (HRT) renders MtF individuals a unique patient subgroup in terms of breast cancer risk. This case describes a MtF transgender who presented with a breast lesion concerning for malignancy following hormonal replacement therapy. The patient additionally had a strong family history of breast cancer. Final pathology revealed lobular hyperplasia in the setting of gynecomastia and pseudoangiomatous stromal hyperplasia (PASH). Both pathology findings are rare in biological females, let alone in the setting of hormone replacement therapy in a MtF individual. While the number of reported cases of suspicious breast lesions in this population remains scarce, it presents both a diagnostic and therapeutic challenge due to the nature of the treatment course and the lack of research in this recently growing subgroup of patients.http://dx.doi.org/10.1155/2017/5172072
collection DOAJ
language English
format Article
sources DOAJ
author Krystina Tongson
Victoria Konovalova
Naveen Dhawan
Steffi Sharma
Jaya Bahl
Mohammad Masri
spellingShingle Krystina Tongson
Victoria Konovalova
Naveen Dhawan
Steffi Sharma
Jaya Bahl
Mohammad Masri
Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion
Case Reports in Oncological Medicine
author_facet Krystina Tongson
Victoria Konovalova
Naveen Dhawan
Steffi Sharma
Jaya Bahl
Mohammad Masri
author_sort Krystina Tongson
title Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion
title_short Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion
title_full Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion
title_fullStr Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion
title_full_unstemmed Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion
title_sort breast cancer suspicion in a transgender male-to-female patient on hormone replacement therapy presenting with right breast mass: breast cancer risk assessment and presentation of a rare lesion
publisher Hindawi Limited
series Case Reports in Oncological Medicine
issn 2090-6706
2090-6714
publishDate 2017-01-01
description There has been an increasing use of hormonal therapy among male-to-female (MtF) transgender individuals. This long-term hormone replacement therapy (HRT) renders MtF individuals a unique patient subgroup in terms of breast cancer risk. This case describes a MtF transgender who presented with a breast lesion concerning for malignancy following hormonal replacement therapy. The patient additionally had a strong family history of breast cancer. Final pathology revealed lobular hyperplasia in the setting of gynecomastia and pseudoangiomatous stromal hyperplasia (PASH). Both pathology findings are rare in biological females, let alone in the setting of hormone replacement therapy in a MtF individual. While the number of reported cases of suspicious breast lesions in this population remains scarce, it presents both a diagnostic and therapeutic challenge due to the nature of the treatment course and the lack of research in this recently growing subgroup of patients.
url http://dx.doi.org/10.1155/2017/5172072
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