Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases

The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous...

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Main Authors:	Juliana de Meis, Désio Aurélio Farias-de-Oliveira, Pedro H. Nunes Panzenhagen, Naiara Maran, Déa Maria Serra Villa-Verde, Alexandre Morrot, Wilson Savino
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Journal of Parasitology Research
Online Access:	http://dx.doi.org/10.1155/2012/574020

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spelling	doaj-0be87314f63c4b15afdf25b75288debf2020-11-24T23:55:58ZengHindawi LimitedJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/574020574020Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious DiseasesJuliana de Meis0Désio Aurélio Farias-de-Oliveira1Pedro H. Nunes Panzenhagen2Naiara Maran3Déa Maria Serra Villa-Verde4Alexandre Morrot5Wilson Savino6Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, BrazilLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, BrazilLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, BrazilDepartment of Immunology, Microbiology Institute, Federal University of Rio de Janeiro, 21941-590 Rio de Janeiro, RJ, BrazilLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, BrazilLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, BrazilLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, BrazilThe thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous factors such as ageing, hormone fluctuations, and infectious agents. This paper will focus on emerging data on the thymic atrophy caused by infectious agents. We present data on the dynamics of thymus lymphocytes during acute Trypanosoma cruzi infection, showing that the resulting thymus atrophy comprises the abnormal release of thymic-derived T cells and may have an impact on host immune response.http://dx.doi.org/10.1155/2012/574020
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Juliana de Meis Désio Aurélio Farias-de-Oliveira Pedro H. Nunes Panzenhagen Naiara Maran Déa Maria Serra Villa-Verde Alexandre Morrot Wilson Savino
spellingShingle	Juliana de Meis Désio Aurélio Farias-de-Oliveira Pedro H. Nunes Panzenhagen Naiara Maran Déa Maria Serra Villa-Verde Alexandre Morrot Wilson Savino Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases Journal of Parasitology Research
author_facet	Juliana de Meis Désio Aurélio Farias-de-Oliveira Pedro H. Nunes Panzenhagen Naiara Maran Déa Maria Serra Villa-Verde Alexandre Morrot Wilson Savino
author_sort	Juliana de Meis
title	Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases
title_short	Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases
title_full	Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases
title_fullStr	Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases
title_full_unstemmed	Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases
title_sort	thymus atrophy and double-positive escape are common features in infectious diseases
publisher	Hindawi Limited
series	Journal of Parasitology Research
issn	2090-0023 2090-0031
publishDate	2012-01-01
description	The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous factors such as ageing, hormone fluctuations, and infectious agents. This paper will focus on emerging data on the thymic atrophy caused by infectious agents. We present data on the dynamics of thymus lymphocytes during acute Trypanosoma cruzi infection, showing that the resulting thymus atrophy comprises the abnormal release of thymic-derived T cells and may have an impact on host immune response.
url	http://dx.doi.org/10.1155/2012/574020
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Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases

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