Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India
Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives: To evaluate the effect of perinatal factors o...
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doaj-0be13faf14254d87ae892d43ff15d7e12020-11-25T02:42:42ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-07-0187PC18PC2010.7860/JCDR/2014/9058.4603Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern IndiaSUNIL RAJ0STEPHENSON BABURAJ1JUMALY GEORGE2BINU ABRAHAM3SUNDAR SINGH4Assistant Professor, Department of Pediatrics, Dr SMCSI Medical College, Trivandrum, Kerala, India.Professor, Department of Pediatrics, Dr SMCSI Medical College, Trivandrum, Kerala, India.Senior Resident, Department of Pediatrics, Rajah Muthiah Medical College and Hospital, Chidambaram, Tamil Nadu, India.Associate Professor, Department of Pediatrics, ESIC Medical College, Paripally, Kerala, India.DM Resident, Division of Neonatology, MOSC Medical College, Kolenchery, Kerala, India.Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives: To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born in a rural tertiary care institution in South India. Methods: A cross-sectional study was done in 430 term neonates at birth to analyse the cord blood TSH levels and a repeat TSH estimation was done on 3rd postnatal day for those having abnormal values. The values were statistically analysed with respect to maternal, paternal and perinatal parameters. Results: The mean value of CBTSH was 12.88 mIU/mL. One hundred twenty five of the 430 neonates (29.06%) were found to have elevated CBTSH levels. Two babies (0.46%) had CBTSH levels below 2.3 mIU/mL. Repeat TSH estimation done on third postnatal day in the 127 babies who had abnormal CBTSH levels revealed only 5 (3.94%) babies had abnormal levels. Serum T4 levels done on the same sample showed abnormal values in 3 (2.67%) babies. CBTSH levels showed no gender varations but increased significantly with the gestational age of the baby (p=0.001). CBTSH levels increased with increasing maternal age (p<0.001) and were significantly higher in babies of mothers with history of hypothyroidism. Conclusion: The incidence of congenital hypothyroidism was 3 in 430 babies, which was high compared to national and international references, highlighting the urgent need of universal screening giving importance to maternal factors also. https://jcdr.net/articles/PDF/4603/9058_CE(Ra1)_F(H)_PF1(PAK)_PFA(P)_PF2(PAG).pdfcongenital hypothyroidismnewborn screening |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
SUNIL RAJ STEPHENSON BABURAJ JUMALY GEORGE BINU ABRAHAM SUNDAR SINGH |
spellingShingle |
SUNIL RAJ STEPHENSON BABURAJ JUMALY GEORGE BINU ABRAHAM SUNDAR SINGH Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India Journal of Clinical and Diagnostic Research congenital hypothyroidism newborn screening |
author_facet |
SUNIL RAJ STEPHENSON BABURAJ JUMALY GEORGE BINU ABRAHAM SUNDAR SINGH |
author_sort |
SUNIL RAJ |
title |
Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India |
title_short |
Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India |
title_full |
Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India |
title_fullStr |
Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India |
title_full_unstemmed |
Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India |
title_sort |
cord blood tsh level variations in newborn – experience from a rural centre in southern india |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2014-07-01 |
description |
Background: Universal screening of all neonates has for
long been recognized as the most effective method to detect
congenital hypothyroidism. However, various maternal as well
as perinatal factors can influence the cord blood TSH levels.
Objectives: To evaluate the effect of perinatal factors on cord
blood TSH level variations in neonates born in a rural tertiary
care institution in South India.
Methods: A cross-sectional study was done in 430 term
neonates at birth to analyse the cord blood TSH levels and a
repeat TSH estimation was done on 3rd postnatal day for those
having abnormal values. The values were statistically analysed
with respect to maternal, paternal and perinatal parameters.
Results: The mean value of CBTSH was 12.88 mIU/mL. One
hundred twenty five of the 430 neonates (29.06%) were found
to have elevated CBTSH levels. Two babies (0.46%) had CBTSH
levels below 2.3 mIU/mL. Repeat TSH estimation done on third
postnatal day in the 127 babies who had abnormal CBTSH
levels revealed only 5 (3.94%) babies had abnormal levels.
Serum T4 levels done on the same sample showed abnormal
values in 3 (2.67%) babies. CBTSH levels showed no gender
varations but increased significantly with the gestational age
of the baby (p=0.001). CBTSH levels increased with increasing
maternal age (p<0.001) and were significantly higher in babies
of mothers with history of hypothyroidism.
Conclusion: The incidence of congenital hypothyroidism
was 3 in 430 babies, which was high compared to national
and international references, highlighting the urgent need of
universal screening giving importance to maternal factors also.
|
topic |
congenital hypothyroidism newborn screening |
url |
https://jcdr.net/articles/PDF/4603/9058_CE(Ra1)_F(H)_PF1(PAK)_PFA(P)_PF2(PAG).pdf |
work_keys_str_mv |
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