Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India

Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives: To evaluate the effect of perinatal factors o...

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Main Authors: SUNIL RAJ, STEPHENSON BABURAJ, JUMALY GEORGE, BINU ABRAHAM, SUNDAR SINGH
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2014-07-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/4603/9058_CE(Ra1)_F(H)_PF1(PAK)_PFA(P)_PF2(PAG).pdf
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spelling doaj-0be13faf14254d87ae892d43ff15d7e12020-11-25T02:42:42ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-07-0187PC18PC2010.7860/JCDR/2014/9058.4603Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern IndiaSUNIL RAJ0STEPHENSON BABURAJ1JUMALY GEORGE2BINU ABRAHAM3SUNDAR SINGH4Assistant Professor, Department of Pediatrics, Dr SMCSI Medical College, Trivandrum, Kerala, India.Professor, Department of Pediatrics, Dr SMCSI Medical College, Trivandrum, Kerala, India.Senior Resident, Department of Pediatrics, Rajah Muthiah Medical College and Hospital, Chidambaram, Tamil Nadu, India.Associate Professor, Department of Pediatrics, ESIC Medical College, Paripally, Kerala, India.DM Resident, Division of Neonatology, MOSC Medical College, Kolenchery, Kerala, India.Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives: To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born in a rural tertiary care institution in South India. Methods: A cross-sectional study was done in 430 term neonates at birth to analyse the cord blood TSH levels and a repeat TSH estimation was done on 3rd postnatal day for those having abnormal values. The values were statistically analysed with respect to maternal, paternal and perinatal parameters. Results: The mean value of CBTSH was 12.88 mIU/mL. One hundred twenty five of the 430 neonates (29.06%) were found to have elevated CBTSH levels. Two babies (0.46%) had CBTSH levels below 2.3 mIU/mL. Repeat TSH estimation done on third postnatal day in the 127 babies who had abnormal CBTSH levels revealed only 5 (3.94%) babies had abnormal levels. Serum T4 levels done on the same sample showed abnormal values in 3 (2.67%) babies. CBTSH levels showed no gender varations but increased significantly with the gestational age of the baby (p=0.001). CBTSH levels increased with increasing maternal age (p<0.001) and were significantly higher in babies of mothers with history of hypothyroidism. Conclusion: The incidence of congenital hypothyroidism was 3 in 430 babies, which was high compared to national and international references, highlighting the urgent need of universal screening giving importance to maternal factors also. https://jcdr.net/articles/PDF/4603/9058_CE(Ra1)_F(H)_PF1(PAK)_PFA(P)_PF2(PAG).pdfcongenital hypothyroidismnewborn screening
collection DOAJ
language English
format Article
sources DOAJ
author SUNIL RAJ
STEPHENSON BABURAJ
JUMALY GEORGE
BINU ABRAHAM
SUNDAR SINGH
spellingShingle SUNIL RAJ
STEPHENSON BABURAJ
JUMALY GEORGE
BINU ABRAHAM
SUNDAR SINGH
Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India
Journal of Clinical and Diagnostic Research
congenital hypothyroidism
newborn screening
author_facet SUNIL RAJ
STEPHENSON BABURAJ
JUMALY GEORGE
BINU ABRAHAM
SUNDAR SINGH
author_sort SUNIL RAJ
title Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India
title_short Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India
title_full Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India
title_fullStr Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India
title_full_unstemmed Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India
title_sort cord blood tsh level variations in newborn – experience from a rural centre in southern india
publisher JCDR Research and Publications Private Limited
series Journal of Clinical and Diagnostic Research
issn 2249-782X
0973-709X
publishDate 2014-07-01
description Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives: To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born in a rural tertiary care institution in South India. Methods: A cross-sectional study was done in 430 term neonates at birth to analyse the cord blood TSH levels and a repeat TSH estimation was done on 3rd postnatal day for those having abnormal values. The values were statistically analysed with respect to maternal, paternal and perinatal parameters. Results: The mean value of CBTSH was 12.88 mIU/mL. One hundred twenty five of the 430 neonates (29.06%) were found to have elevated CBTSH levels. Two babies (0.46%) had CBTSH levels below 2.3 mIU/mL. Repeat TSH estimation done on third postnatal day in the 127 babies who had abnormal CBTSH levels revealed only 5 (3.94%) babies had abnormal levels. Serum T4 levels done on the same sample showed abnormal values in 3 (2.67%) babies. CBTSH levels showed no gender varations but increased significantly with the gestational age of the baby (p=0.001). CBTSH levels increased with increasing maternal age (p<0.001) and were significantly higher in babies of mothers with history of hypothyroidism. Conclusion: The incidence of congenital hypothyroidism was 3 in 430 babies, which was high compared to national and international references, highlighting the urgent need of universal screening giving importance to maternal factors also.
topic congenital hypothyroidism
newborn screening
url https://jcdr.net/articles/PDF/4603/9058_CE(Ra1)_F(H)_PF1(PAK)_PFA(P)_PF2(PAG).pdf
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