ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development

ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development

ATM is among of the most critical initiators and coordinators of the DNA-damage response. ATM canonical and non-canonical signaling pathways involve hundreds of downstream targets that control many important cellular processes such as DNA damage repair, apoptosis, cell cycle arrest, metabolism, prol...

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Bibliographic Details
Main Authors: Liem Minh Phan, Abdol-Hossein Rezaeian
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Genes
Subjects:
ATM
cancer
DNA damage repair
DNA damage response
oxidative sensing
autophagy
Online Access:https://www.mdpi.com/2073-4425/12/6/845

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