Effects of physical and chemical factors on pseudorabies virus activity in vitro

Abstract Background Pseudorabies (PR) is latent and can persist in infected sows for a long time, and thus, convalescent sows can carry the virus throughout life, causing severe economic losses to farmers and posing a tremendous challenge to PR prevention and control. Here, to investigate the biolog...

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Main Authors: Lang Gong, Qiwei Deng, Runda Xu, Chihai Ji, Heng Wang, Guihong Zhang
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Veterinary Research
Subjects:
PRV
Online Access:http://link.springer.com/article/10.1186/s12917-020-02573-3
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spelling doaj-0bd76faad0824622855ef8ceb2d23f8c2020-11-25T03:48:38ZengBMCBMC Veterinary Research1746-61482020-09-0116111010.1186/s12917-020-02573-3Effects of physical and chemical factors on pseudorabies virus activity in vitroLang Gong0Qiwei Deng1Runda Xu2Chihai Ji3Heng Wang4Guihong Zhang5College of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityCollege of Veterinary Medicine, South China Agricultural UniversityAbstract Background Pseudorabies (PR) is latent and can persist in infected sows for a long time, and thus, convalescent sows can carry the virus throughout life, causing severe economic losses to farmers and posing a tremendous challenge to PR prevention and control. Here, to investigate the biological characteristics of pseudorabies virus (PRV), a variety of physical and chemical factors were analyzed under controlled conditions. Results The results showed that a high ambient temperature and dry environment led to faster virus inactivation. PRV had a certain resistance to weakly acidic or alkaline environments and was rapidly inactivated in strongly acidic or alkaline environments. The effect of ultraviolet (UV) radiation on PRV activity primarily depended on the frequency, intensity, and irradiation time of the UV exposure. Exposure to sunlight inactivated PRV via multiple factors, including temperature, sunlight intensity, UV intensity, and environmental humidity, and any shielding from sunlight strongly lowered the killing effect. Conventional disinfectants had a good disinfection effect on PRV. Conclusions The biological characteristics of different PRV strains are variable. Generally, the activity of PRV is affected by multiple factors, which can show both synergy and antagonism. Real-world conditions should be taken into consideration to guide pork production.http://link.springer.com/article/10.1186/s12917-020-02573-3PRVBiological characteristicsPhysical and chemical factors
collection DOAJ
language English
format Article
sources DOAJ
author Lang Gong
Qiwei Deng
Runda Xu
Chihai Ji
Heng Wang
Guihong Zhang
spellingShingle Lang Gong
Qiwei Deng
Runda Xu
Chihai Ji
Heng Wang
Guihong Zhang
Effects of physical and chemical factors on pseudorabies virus activity in vitro
BMC Veterinary Research
PRV
Biological characteristics
Physical and chemical factors
author_facet Lang Gong
Qiwei Deng
Runda Xu
Chihai Ji
Heng Wang
Guihong Zhang
author_sort Lang Gong
title Effects of physical and chemical factors on pseudorabies virus activity in vitro
title_short Effects of physical and chemical factors on pseudorabies virus activity in vitro
title_full Effects of physical and chemical factors on pseudorabies virus activity in vitro
title_fullStr Effects of physical and chemical factors on pseudorabies virus activity in vitro
title_full_unstemmed Effects of physical and chemical factors on pseudorabies virus activity in vitro
title_sort effects of physical and chemical factors on pseudorabies virus activity in vitro
publisher BMC
series BMC Veterinary Research
issn 1746-6148
publishDate 2020-09-01
description Abstract Background Pseudorabies (PR) is latent and can persist in infected sows for a long time, and thus, convalescent sows can carry the virus throughout life, causing severe economic losses to farmers and posing a tremendous challenge to PR prevention and control. Here, to investigate the biological characteristics of pseudorabies virus (PRV), a variety of physical and chemical factors were analyzed under controlled conditions. Results The results showed that a high ambient temperature and dry environment led to faster virus inactivation. PRV had a certain resistance to weakly acidic or alkaline environments and was rapidly inactivated in strongly acidic or alkaline environments. The effect of ultraviolet (UV) radiation on PRV activity primarily depended on the frequency, intensity, and irradiation time of the UV exposure. Exposure to sunlight inactivated PRV via multiple factors, including temperature, sunlight intensity, UV intensity, and environmental humidity, and any shielding from sunlight strongly lowered the killing effect. Conventional disinfectants had a good disinfection effect on PRV. Conclusions The biological characteristics of different PRV strains are variable. Generally, the activity of PRV is affected by multiple factors, which can show both synergy and antagonism. Real-world conditions should be taken into consideration to guide pork production.
topic PRV
Biological characteristics
Physical and chemical factors
url http://link.springer.com/article/10.1186/s12917-020-02573-3
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