Biocompatible anionic polymeric microspheres as priming delivery system for effetive HIV/AIDS Tat-based vaccines.

Biocompatible anionic polymeric microspheres as priming delivery system for effetive HIV/AIDS Tat-based vaccines.

Here we describe a prime-boost regimen of vaccination in Macaca fascicularis that combines priming with novel anionic microspheres designed to deliver the biologically active HIV-1 Tat protein and boosting with Tat in Alum. This regimen of immunization modulated the IgG subclass profile and elicited...

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Bibliographic Details
Main Authors: Fausto Titti, Maria T Maggiorella, Flavia Ferrantelli, Leonardo Sernicola, Stefania Bellino, Barbara Collacchi, Emanuele Fanales Belasio, Sonia Moretti, Maria Rosaria Pavone Cossut, Roberto Belli, Erika Olivieri, Stefania Farcomeni, Daniela Compagnoni, Zuleika Michelini, Michela Sabbatucci, Katia Sparnacci, Luisa Tondelli, Michele Laus, Aurelio Cafaro, Antonella Caputo, Barbara Ensoli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4214729?pdf=render

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