Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC)
In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
1994-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000591 |
| Summary: | In addition to the spectrum of biological action already known to be
exhibited by acetylsalicylic acid (ASA) as an analgesic,
anti-inflammatory and platelet aggregation inhibitor, there is
growing evidence of a stimulatory effect on the immune system. ASA
has been found to increase the production ofcytokines and to
increase the activity of various leukocytes. The action of ASA on
the activity of mouse peritoneal macrophages was therefore
investigated in the present study. Therapeutically effective
concentrations of ASA, which are known to decrease levels of
prostaglandins, had neither a stimulating nor an inhibiting
influence on antibody-dependent cellular cytotoxicity (ADCC) or on
the binding capacity of macrophages with regard to SW 948 tumour
cells. Likewise ASA had little or no adverse effect on the capacity
of the macrophages for stimulation by interferon-gamma (IFN-gamma)
and interleukin-4 (IL-4). Taken together, the immunostimulant effect
of ASA shown in the literature as an increased production of
interleukin-2 (IL-2) and IFN, could not be confirmed on the basis of
the macrophage cytotoxiclty. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |