Determination of complete chromosomal haplotypes by bulk DNA sequencing

Determination of complete chromosomal haplotypes by bulk DNA sequencing

Abstract Haplotype phase represents the collective genetic variation between homologous chromosomes and is an essential feature of non-haploid genomes. Here we describe a computational strategy to reliably determine complete whole-chromosome haplotypes using a combination of bulk long-range sequenci...

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Bibliographic Details
Main Authors:	Richard W. Tourdot, Gregory J. Brunette, Ricardo A. Pinto, Cheng-Zhong Zhang
Format:	Article
Language:	English
Published:	BMC 2021-05-01
Series:	Genome Biology
Subjects:	Haplotype Chromosome rearrangement Cancer genomics
Online Access:	https://doi.org/10.1186/s13059-021-02330-1

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