Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis Study

Background: Glucose-6-phosphate dehydrogenase is one of the most common genetic deficiencies, which approximately 400 million people in the world suffer from. According to authors' initial search, numerous studies have been carried out in Iran regarding molecular variants of this enzyme. Thus,...

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Main Authors: Mahmood Moosazadeh, Mahmood Nekoei-Moghadam, Maryam Aliramzany, Mohammadreza Amiresmaili
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2013-09-01
Series:Iranian Journal of Public Health
Subjects:
Online Access:http://ijph.tums.ac.ir/index.php/IJPH/article/view/4139/2221
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spelling doaj-0bb54d8a587f45728e9c0774fadb330e2020-12-02T07:05:32ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852013-09-0142910071015Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis StudyMahmood MoosazadehMahmood Nekoei-MoghadamMaryam AliramzanyMohammadreza AmiresmailiBackground: Glucose-6-phosphate dehydrogenase is one of the most common genetic deficiencies, which approximately 400 million people in the world suffer from. According to authors' initial search, numerous studies have been carried out in Iran regarding molecular variants of this enzyme. Thus, this meta-analysis presented a reliable estimation about prevalence of different types of molecular mutations of G6PD Enzyme in Iran.Methods: Keywords "glucose 6 phosphate dehydrogenase or G6PD, Mediterranean or Chatham or Cosenza and mutation, Iran or Iranian and their Persian equivalents" were searched in different databases. Moreover, reference list of the published studies were examined to increase sensitivity and to select more studies. After studying titles and abstracts of retrieved articles, excluding the repeated and unrelated ones, and evaluating quality of articles, documents were selected. Data was analyzed using STATA.Results: After performing systematic review, 22 papers were entered this meta-analysis and 1698 subjects were examined concerning G6PD molecular mutation. In this meta-analysis, prevalence of Mediterranean mutation, Chatham mutation and Cosenza mutation in Iran was estimated 78.2%, 9.1% and 0.5% respectively.Conclusions: This meta-analysis showed that in spite of prevalence of different types of G6PD molecular mutations in center, north, north-west and west of Iran, the most common molecular mutations in people with G6PD deficiency in Iran, like other Mediterranean countries and countries around Persian Gulf, were Mediterranean mutation, Chatham mutation and Cosenza mutation. It is also recommended that future studies may focus on races and regions which haven't been taken into consideration up to now.http://ijph.tums.ac.ir/index.php/IJPH/article/view/4139/2221G6PDMediterraneanChathamCosenzaMutationIran
collection DOAJ
language English
format Article
sources DOAJ
author Mahmood Moosazadeh
Mahmood Nekoei-Moghadam
Maryam Aliramzany
Mohammadreza Amiresmaili
spellingShingle Mahmood Moosazadeh
Mahmood Nekoei-Moghadam
Maryam Aliramzany
Mohammadreza Amiresmaili
Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis Study
Iranian Journal of Public Health
G6PD
Mediterranean
Chatham
Cosenza
Mutation
Iran
author_facet Mahmood Moosazadeh
Mahmood Nekoei-Moghadam
Maryam Aliramzany
Mohammadreza Amiresmaili
author_sort Mahmood Moosazadeh
title Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis Study
title_short Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis Study
title_full Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis Study
title_fullStr Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis Study
title_full_unstemmed Identification of Mutation of Glucose-6-Phosphate Dehy-drogenase (G6PD) in Iran: Meta- analysis Study
title_sort identification of mutation of glucose-6-phosphate dehy-drogenase (g6pd) in iran: meta- analysis study
publisher Tehran University of Medical Sciences
series Iranian Journal of Public Health
issn 2251-6085
publishDate 2013-09-01
description Background: Glucose-6-phosphate dehydrogenase is one of the most common genetic deficiencies, which approximately 400 million people in the world suffer from. According to authors' initial search, numerous studies have been carried out in Iran regarding molecular variants of this enzyme. Thus, this meta-analysis presented a reliable estimation about prevalence of different types of molecular mutations of G6PD Enzyme in Iran.Methods: Keywords "glucose 6 phosphate dehydrogenase or G6PD, Mediterranean or Chatham or Cosenza and mutation, Iran or Iranian and their Persian equivalents" were searched in different databases. Moreover, reference list of the published studies were examined to increase sensitivity and to select more studies. After studying titles and abstracts of retrieved articles, excluding the repeated and unrelated ones, and evaluating quality of articles, documents were selected. Data was analyzed using STATA.Results: After performing systematic review, 22 papers were entered this meta-analysis and 1698 subjects were examined concerning G6PD molecular mutation. In this meta-analysis, prevalence of Mediterranean mutation, Chatham mutation and Cosenza mutation in Iran was estimated 78.2%, 9.1% and 0.5% respectively.Conclusions: This meta-analysis showed that in spite of prevalence of different types of G6PD molecular mutations in center, north, north-west and west of Iran, the most common molecular mutations in people with G6PD deficiency in Iran, like other Mediterranean countries and countries around Persian Gulf, were Mediterranean mutation, Chatham mutation and Cosenza mutation. It is also recommended that future studies may focus on races and regions which haven't been taken into consideration up to now.
topic G6PD
Mediterranean
Chatham
Cosenza
Mutation
Iran
url http://ijph.tums.ac.ir/index.php/IJPH/article/view/4139/2221
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AT maryamaliramzany identificationofmutationofglucose6phosphatedehydrogenaseg6pdiniranmetaanalysisstudy
AT mohammadrezaamiresmaili identificationofmutationofglucose6phosphatedehydrogenaseg6pdiniranmetaanalysisstudy
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