Modulation of Tubular pH by Acetazolamide in a Ca<sup>2+</sup> Transport Deficient Mice Facilitates Calcium Nephrolithiasis

Modulation of Tubular pH by Acetazolamide in a Ca<sup>2+</sup> Transport Deficient Mice Facilitates Calcium Nephrolithiasis

Proximal tubular (PT) acidosis, which alkalinizes the urinary filtrate, together with Ca<sup>2+</sup> supersaturation in PT can induce luminal calcium phosphate (CaP) crystal formation. While such CaP crystals are known to act as a nidus for CaP/calcium oxalate (CaOx) mixed stone formati...

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Bibliographic Details
Main Authors: Eugenia Awuah Boadi, Samuel Shin, Samuel Yeroushalmi, Bok-Eum Choi, Peijun Li, Bidhan C. Bandyopadhyay
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
acetazolamide
renal tubular pH
proximal tubule
Ca<sup>2+</sup> signaling
oxidative stress
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/6/3050

Internet

https://www.mdpi.com/1422-0067/22/6/3050

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