Independent control of the thermodynamic and kinetic properties of aptamer switches

Independent control of the thermodynamic and kinetic properties of aptamer switches

Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.

Bibliographic Details
Main Authors: Brandon D. Wilson, Amani A. Hariri, Ian A. P. Thompson, Michael Eisenstein, H. Tom Soh
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13137-x
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spelling doaj-0ba91a767197432caebcff4ce0b2b98c2021-05-11T11:39:59ZengNature Publishing GroupNature Communications2041-17232019-11-011011910.1038/s41467-019-13137-xIndependent control of the thermodynamic and kinetic properties of aptamer switchesBrandon D. Wilson0Amani A. Hariri1Ian A. P. Thompson2Michael Eisenstein3H. Tom Soh4Department of Chemical Engineering, Stanford UniversityDepartment of Electrical Engineering, Stanford UniversityDepartment of Electrical Engineering, Stanford UniversityDepartment of Electrical Engineering, Stanford UniversityDepartment of Electrical Engineering, Stanford UniversityAptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.https://doi.org/10.1038/s41467-019-13137-x
collection DOAJ
language English
format Article
sources DOAJ
author Brandon D. Wilson
Amani A. Hariri
Ian A. P. Thompson
Michael Eisenstein
H. Tom Soh
spellingShingle Brandon D. Wilson
Amani A. Hariri
Ian A. P. Thompson
Michael Eisenstein
H. Tom Soh
Independent control of the thermodynamic and kinetic properties of aptamer switches
Nature Communications
author_facet Brandon D. Wilson
Amani A. Hariri
Ian A. P. Thompson
Michael Eisenstein
H. Tom Soh
author_sort Brandon D. Wilson
title Independent control of the thermodynamic and kinetic properties of aptamer switches
title_short Independent control of the thermodynamic and kinetic properties of aptamer switches
title_full Independent control of the thermodynamic and kinetic properties of aptamer switches
title_fullStr Independent control of the thermodynamic and kinetic properties of aptamer switches
title_full_unstemmed Independent control of the thermodynamic and kinetic properties of aptamer switches
title_sort independent control of the thermodynamic and kinetic properties of aptamer switches
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-11-01
description Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.
url https://doi.org/10.1038/s41467-019-13137-x
work_keys_str_mv AT brandondwilson independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches
AT amaniahariri independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches
AT ianapthompson independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches
AT michaeleisenstein independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches
AT htomsoh independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches
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