Structure of the human sodium leak channel NALCN in complex with FAM155A

Structure of the human sodium leak channel NALCN in complex with FAM155A

NALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity,...

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Bibliographic Details
Main Authors: Jiongfang Xie, Meng Ke, Lizhen Xu, Shiyi Lin, Jin Huang, Jiabei Zhang, Fan Yang, Jianping Wu, Zhen Yan
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19667-z
Description
Summary:NALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity, voltage sensing and specific interactions with auxiliary subunits.
ISSN:2041-1723

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