Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which respo...

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Main Authors:	Yujin Park, Kang Moo Huh, Sun-Woong Kang
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	International Journal of Molecular Sciences
Subjects:	3D cell culture biomaterials drug screening alternative model
Online Access:	https://www.mdpi.com/1422-0067/22/5/2491

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spelling	doaj-0ba0917196b747bebcf8aab29ed471c72021-03-03T00:01:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01222491249110.3390/ijms22052491Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical ResearchYujin Park0Kang Moo Huh1Sun-Woong Kang2Department of Polymer Science and Engineering & Chemical Engineering and Applied Chemistry, Chungnam National University, Daejeon 34134, KoreaDepartment of Polymer Science and Engineering & Chemical Engineering and Applied Chemistry, Chungnam National University, Daejeon 34134, KoreaPredictive Model Research Center, Korea Institute of Toxicology, Daejeon 34114, KoreaThe process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.https://www.mdpi.com/1422-0067/22/5/24913D cell culturebiomaterialsdrug screeningalternative model
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yujin Park Kang Moo Huh Sun-Woong Kang
spellingShingle	Yujin Park Kang Moo Huh Sun-Woong Kang Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research International Journal of Molecular Sciences 3D cell culture biomaterials drug screening alternative model
author_facet	Yujin Park Kang Moo Huh Sun-Woong Kang
author_sort	Yujin Park
title	Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_short	Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_full	Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_fullStr	Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_full_unstemmed	Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_sort	applications of biomaterials in 3d cell culture and contributions of 3d cell culture to drug development and basic biomedical research
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1661-6596 1422-0067
publishDate	2021-03-01
description	The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.
topic	3D cell culture biomaterials drug screening alternative model
url	https://www.mdpi.com/1422-0067/22/5/2491
work_keys_str_mv	AT yujinpark applicationsofbiomaterialsin3dcellcultureandcontributionsof3dcellculturetodrugdevelopmentandbasicbiomedicalresearch AT kangmoohuh applicationsofbiomaterialsin3dcellcultureandcontributionsof3dcellculturetodrugdevelopmentandbasicbiomedicalresearch AT sunwoongkang applicationsofbiomaterialsin3dcellcultureandcontributionsof3dcellculturetodrugdevelopmentandbasicbiomedicalresearch
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Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

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