Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling

Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling

Acetylshikonin, a natural naphthoquinone derivative compound from Lithospermum erythrorhyzon, has been reported to kill bacteria, suppress inflammation, and inhibit tumor growth. However, the effect of acetylshikonin on human chronic myelocytic leukemia (CML) cells apoptosis and its detailed mechani...

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Bibliographic Details
Main Authors: Gangping Hao, Jing Zhai, Hanming Jiang, Yuanying Zhang, Mengdi Wu, Yuyu Qiu, Cundong Fan, Lijuan Yu, Suyun Bai, Lingyun Sun, Zhongfa Yang
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acetylshikonin
K562 cells
Cell cycle
Apoptosis
ROS
Bcr-Abl and NF-κB signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219352990

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http://www.sciencedirect.com/science/article/pii/S0753332219352990

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