Antithyroid Antibodies and Fertility Outcome in Euthyroid Women Undergoing In Vitro Fertilisation

• Main Authors: Aheibam Bidya Devi, Sudha Prasad, Bidhan Chandra Koner
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2019-05-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: anti-thyroglobulin antibody; anti-thyroperoxidase antibody; pregnancy rate
• Online Access: https://jcdr.net/articles/PDF/12872/40760_CE[Ra1]_F(AC_RV_SL)_PF1(AG_SHU)_GC(RV_SL)_PN(SL).pdf
• ISSN: 2249-782X; 0973-709X

Introduction: Antithyroid Antibodies (ATA) are suspected to cause poor outcome of In Vitro Fertilisation (IVF) even in the absence of thyroid dysfunction. Aim: To study the effect of ATA on fertilisation rate, implantation rate and clinical pregnancy rate in euthyroid women undergoing IVF. Materials and Methods: The study was a prospective cohort study conducted at an IVF centre of a Medical College. A total of 81 euthyroid patients planned for IVF were recruited and divided into two groups depending upon the presence of ATA. All of them underwent the standard stimulation protocol. The results were compared using unpaired t-test for continuous variables and Chi-square/Fishers’-exact test for categorical variables. Results: The prevalence of ATA was 20.99% (17/81) in our study population. The fertilisation rate was significantly lower (p<0.05) in women with ATA (66.3% versus 78.9%). However, no statistically significant difference was observed in implantation rate (18.2% versus 26.8%) and clinical pregnancy rate (31.3% versus 39.3%). Conclusion: The presence of ATA was associated with a lower fertilisation rate even in euthyroid state in women undergoing IVF. However, the implantation and clinical pregnancy rate were not correlated with the presence of such antibodies.