Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion molecules

Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion molecules

HopQ is an outer-membrane protein of Helicobacter pylori that binds to human carcinoembryonic antigen-related cell-adhesion molecules (CEACAMs) with high specificity. We aimed to investigate fluorescence targeting of CEACAM-expressing colorectal tumors in patient-derived orthotopic xenograft (PDOX)...

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Bibliographic Details
Main Authors: Hannah M. Hollandsworth, Verena Schmitt, Siamak Amirfakhri, Filemoni Filemoni, Alexej Schmidt, Maréne Landström, Mykola Lyndin, Steffen Backert, Markus Gerhard, Gunther Wennemuth, Robert M. Hoffman, Bernhard B. Singer, Michael Bouvet
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320303491

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