Assessing imprecision in Cochrane systematic reviews: a comparison of GRADE and Trial Sequential Analysis

Assessing imprecision in Cochrane systematic reviews: a comparison of GRADE and Trial Sequential Analysis

Abstract Background The evaluation of imprecision is a key dimension of the grading of the confidence in the estimate. Grading of Recommendations Assessment, Development and Evaluation (GRADE) gives recommendations on how to downgrade evidence for imprecision, but authors vary in their use. Trial Se...

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Bibliographic Details
Main Authors: Greta Castellini, Matteo Bruschettini, Silvia Gianola, Christian Gluud, Lorenzo Moja
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Systematic Reviews
Subjects:
Review
Meta-analysis
Bias
Confidence intervals
Epidemiologic methods
Online Access:http://link.springer.com/article/10.1186/s13643-018-0770-1

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