The Divergent Effects of CDPPB and Cannabidiol on Fear Extinction and Anxiety in a Predator Scent Stress Model of PTSD in Rats

The Divergent Effects of CDPPB and Cannabidiol on Fear Extinction and Anxiety in a Predator Scent Stress Model of PTSD in Rats

Post-traumatic stress disorder (PTSD) currently has no FDA-approved treatments that reduce symptoms in the majority of patients. The ability to extinguish fear memory associations is impaired in PTSD individuals. As such, the development of extinction-enhancing pharmacological agents to be used in c...

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Bibliographic Details
Main Authors: John Shallcross, Peter Hámor, Allison R. Bechard, Madison Romano, Lori Knackstedt, Marek Schwendt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
fear extinction
TMT
resilient
mGlu5
mPFC
BLA
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00091/full

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