Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies

Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies

Duchenne muscular dystrophy (DMD) is an X-linked recessive disease resulting in the loss of dystrophin, a key cytoskeletal protein in the dystrophin-glycoprotein complex. Dystrophin connects the extracellular matrix with the cytoskeleton and stabilizes the sarcolemma. Cardiomyopathy is prominent in...

Full description

Bibliographic Details
Main Authors: Michelle L. Law, Houda Cohen, Ashley A. Martin, Addeli Bez Batti Angulski, Joseph M. Metzger
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Journal of Clinical Medicine
Subjects:
dilated cardiomyopathy
muscular dystrophy
calcium
heart
gene therapy
phospholamban
serca2a
<i>mdx</i>
oxidative stress
membrane stabilization
Online Access:https://www.mdpi.com/2077-0383/9/2/520

Internet

https://www.mdpi.com/2077-0383/9/2/520

Similar Items