Creatinine Trends to Detect Ibuprofen-Related Maturational Adverse Drug Events in Neonatal Life: A Simulation Study for the ELBW Newborn

Creatinine Trends to Detect Ibuprofen-Related Maturational Adverse Drug Events in Neonatal Life: A Simulation Study for the ELBW Newborn

Background: Recognizing a change in serum creatinine concentrations is useful to detect a renal adverse drug reaction signal. Assessing and characterizing the nephrotoxic side-effects of drugs in extremely low birth weight (ELBW, ≤1000 g) neonates remain challenging due to the high variability in cr...

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Bibliographic Details
Main Authors: Tamara van Donge, Karel Allegaert, Marc Pfister, Anne Smits, John van den Anker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
serum creatinine
ibuprofen
nephrotoxicity
creatinine clearance
ELBW neonates
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.610294/full

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