In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis

In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis

The biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear. Here, the authors report in vivo and in vitro evidence for unique steps in cystobactamid biosynthesis.

Bibliographic Details
Main Authors: Sebastian Groß, Bastien Schnell, Patrick A. Haack, David Auerbach, Rolf Müller
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21848-3
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spelling doaj-0b7437a9990648c78f101efed6acc7c32021-03-21T12:13:45ZengNature Publishing GroupNature Communications2041-17232021-03-0112111510.1038/s41467-021-21848-3In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesisSebastian Groß0Bastien Schnell1Patrick A. Haack2David Auerbach3Rolf Müller4Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland UniversityHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland UniversityHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland UniversityHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland UniversityHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland UniversityThe biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear. Here, the authors report in vivo and in vitro evidence for unique steps in cystobactamid biosynthesis.https://doi.org/10.1038/s41467-021-21848-3
collection DOAJ
language English
format Article
sources DOAJ
author Sebastian Groß
Bastien Schnell
Patrick A. Haack
David Auerbach
Rolf Müller
spellingShingle Sebastian Groß
Bastien Schnell
Patrick A. Haack
David Auerbach
Rolf Müller
In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
Nature Communications
author_facet Sebastian Groß
Bastien Schnell
Patrick A. Haack
David Auerbach
Rolf Müller
author_sort Sebastian Groß
title In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_short In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_full In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_fullStr In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_full_unstemmed In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_sort in vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description The biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear. Here, the authors report in vivo and in vitro evidence for unique steps in cystobactamid biosynthesis.
url https://doi.org/10.1038/s41467-021-21848-3
work_keys_str_mv AT sebastiangroß invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis
AT bastienschnell invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis
AT patrickahaack invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis
AT davidauerbach invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis
AT rolfmuller invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis
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