An altered gp100 peptide ligand with decreased binding by TCR and CD8alpha dissects T cell cytotoxicity from production of cytokines and activation of NFAT

An altered gp100 peptide ligand with decreased binding by TCR and CD8alpha dissects T cell cytotoxicity from production of cytokines and activation of NFAT

Altered peptide ligands (APLs) provide useful tools to study T cell activation and potentially direct immune responses to improve treatment of cancer patients. To better understand and exploit APLs, we studied the relationship between APLs and T cell function in more detail. Here, we tested a broad...

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Bibliographic Details
Main Authors: Niels eSchaft, miriam eCoccoris, Joost eDrexhage, Christiaan eKnoop, Jolanda M de Vries, Gosse J Adema, Reno eDebets
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
Cytotoxicity
T cell receptor (TCR)
cytokine production
TCR gene transfer
peptide fine-specificity
human T lymphocytes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00270/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00270/full

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