Combined chemotherapy and irradiation in anaplastic thyroid carcinoma
Background: Anaplastic thyroid carcinoma (ATC) is a very rare and extremely aggressive cancer; patient's death usually occurs rapidly after diagnosis with a mean survival of six months in the majority of individual research series. Treatment of ATC ranges from surgery, radiotherapy, chemotherap...
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Institute of Oncology, Sremska Kamenica, Serbia
2003-01-01
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doaj-0b6ca68faa1349d4ad8be91613835fa72020-11-25T01:05:27ZengInstitute of Oncology, Sremska Kamenica, SerbiaArchive of Oncology0354-73102003-01-0111318718710.2298/AOO0303187PCombined chemotherapy and irradiation in anaplastic thyroid carcinomaPejčić IvicaVrbić SvetislavŠćekić MirjanaBackground: Anaplastic thyroid carcinoma (ATC) is a very rare and extremely aggressive cancer; patient's death usually occurs rapidly after diagnosis with a mean survival of six months in the majority of individual research series. Treatment of ATC ranges from surgery, radiotherapy, chemotherapy, or a combination of these regimes. Yet, the optimal sequence of treatment modalities has not been established. Methods: From 1997 to 2002 six consecutive patients with a histological diagnosis of ATC were treated with combined chemotherapy and irradiation at our Clinic for Oncology, Clinical Center Ni¹. Five of these patients were females and 1 male, aged between 28 and 71 years (mean age: 57 years). None of them had distant metastases at the time of diagnosis. Extrathyroidal extension was present in 3 patients with invasion into skin and hypoderm. Treatment consisted of doxorubicin 60 mg/m 2 plus cisplatin 60 mg/m 2 every three weeks. Total doses ranged between 158-375 mg/m 2 for doxorubicin and 183-380 mg/m 2 for cisplatin. External beam radiation to the neck was administered, at a daily dose of 1.2 Gy, up to total doses ranging between 45-60 Gy. Results: One patient achieved a complete response (CR) and one patient achieved a partial response (PR). Three patients had stable disease. One patient with CR progressed during follow-up and died 18 months from bone and brain metastases. The treatment was moderately well tolerated, although all patients experienced some mild form of toxicity; neutropenia occurred in all patients, but none of them required hospital admission. Median survival was 8 months (range: 4-18 months). Conclusion: We concluded that the present regimen produces meaningful responses for patients with localized ATC. A randomized study is needed to determine the effect on survival. http://www.doiserbia.nb.rs/img/doi/0354-7310/2003/0354-73100303187P.pdfthyroid neoplasmscarcinomaradiotherapyantineoplastic combined chemotherapy protocols |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pejčić Ivica Vrbić Svetislav Šćekić Mirjana |
spellingShingle |
Pejčić Ivica Vrbić Svetislav Šćekić Mirjana Combined chemotherapy and irradiation in anaplastic thyroid carcinoma Archive of Oncology thyroid neoplasms carcinoma radiotherapy antineoplastic combined chemotherapy protocols |
author_facet |
Pejčić Ivica Vrbić Svetislav Šćekić Mirjana |
author_sort |
Pejčić Ivica |
title |
Combined chemotherapy and irradiation in anaplastic thyroid carcinoma |
title_short |
Combined chemotherapy and irradiation in anaplastic thyroid carcinoma |
title_full |
Combined chemotherapy and irradiation in anaplastic thyroid carcinoma |
title_fullStr |
Combined chemotherapy and irradiation in anaplastic thyroid carcinoma |
title_full_unstemmed |
Combined chemotherapy and irradiation in anaplastic thyroid carcinoma |
title_sort |
combined chemotherapy and irradiation in anaplastic thyroid carcinoma |
publisher |
Institute of Oncology, Sremska Kamenica, Serbia |
series |
Archive of Oncology |
issn |
0354-7310 |
publishDate |
2003-01-01 |
description |
Background: Anaplastic thyroid carcinoma (ATC) is a very rare and extremely aggressive cancer; patient's death usually occurs rapidly after diagnosis with a mean survival of six months in the majority of individual research series. Treatment of ATC ranges from surgery, radiotherapy, chemotherapy, or a combination of these regimes. Yet, the optimal sequence of treatment modalities has not been established. Methods: From 1997 to 2002 six consecutive patients with a histological diagnosis of ATC were treated with combined chemotherapy and irradiation at our Clinic for Oncology, Clinical Center Ni¹. Five of these patients were females and 1 male, aged between 28 and 71 years (mean age: 57 years). None of them had distant metastases at the time of diagnosis. Extrathyroidal extension was present in 3 patients with invasion into skin and hypoderm. Treatment consisted of doxorubicin 60 mg/m 2 plus cisplatin 60 mg/m 2 every three weeks. Total doses ranged between 158-375 mg/m 2 for doxorubicin and 183-380 mg/m 2 for cisplatin. External beam radiation to the neck was administered, at a daily dose of 1.2 Gy, up to total doses ranging between 45-60 Gy. Results: One patient achieved a complete response (CR) and one patient achieved a partial response (PR). Three patients had stable disease. One patient with CR progressed during follow-up and died 18 months from bone and brain metastases. The treatment was moderately well tolerated, although all patients experienced some mild form of toxicity; neutropenia occurred in all patients, but none of them required hospital admission. Median survival was 8 months (range: 4-18 months). Conclusion: We concluded that the present regimen produces meaningful responses for patients with localized ATC. A randomized study is needed to determine the effect on survival. |
topic |
thyroid neoplasms carcinoma radiotherapy antineoplastic combined chemotherapy protocols |
url |
http://www.doiserbia.nb.rs/img/doi/0354-7310/2003/0354-73100303187P.pdf |
work_keys_str_mv |
AT pejcicivica combinedchemotherapyandirradiationinanaplasticthyroidcarcinoma AT vrbicsvetislav combinedchemotherapyandirradiationinanaplasticthyroidcarcinoma AT scekicmirjana combinedchemotherapyandirradiationinanaplasticthyroidcarcinoma |
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