Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.

Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.

T cell activation and immune synapse formation require the appropriate activation and clustering of the integrin, LFA-1. Previous work has reported that the calpain family of calcium-dependent proteases are important regulators of integrin activation and modulate T cell adhesion and migration. Howev...

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Bibliographic Details
Main Authors: Sarah A Wernimont, William T N Simonson, Peter A Greer, Christine M Seroogy, Anna Huttenlocher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2866319?pdf=render

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