Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis

Objective: To determine if bicarbonate values from venous blood gas (VBG) and plasma chemistry samples provided agreement in determining the bicarbonate criteria for the diagnosis and/or resolution of diabetic ketoacidosis (DKA). Methods: A retrospective chart review of data from patients admitted t...

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Main Authors: Poorani Nallam Goundan, Devina Luhur Willard, Ayse Sahin-Efe, Shu-Ling Liang Fan, Sara Michelle Alexanian
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Journal of Clinical & Translational Endocrinology
Online Access:http://www.sciencedirect.com/science/article/pii/S2214623719300687
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spelling doaj-0b695ff4418b4e9e94c3e362133b82ce2020-11-25T01:44:34ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372019-12-0118Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosisPoorani Nallam Goundan0Devina Luhur Willard1Ayse Sahin-Efe2Shu-Ling Liang Fan3Sara Michelle Alexanian4Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston University Medical Center, 720 Harrison Ave, Doctors Office Building, #8100, Boston, MA 02118, United States; Corresponding author.Department of Endocrinology, South Shore Health, Norwell, MA, United StatesSection of Endocrinology, Mount Auburn Hospital, Cambridge, MA, United StatesDepartment of Pathology, UMass Memorial Medical Center, Worcester, MA 01605, United StatesSection of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston University Medical Center, 720 Harrison Ave, Doctors Office Building, #8100, Boston, MA 02118, United StatesObjective: To determine if bicarbonate values from venous blood gas (VBG) and plasma chemistry samples provided agreement in determining the bicarbonate criteria for the diagnosis and/or resolution of diabetic ketoacidosis (DKA). Methods: A retrospective chart review of data from patients admitted to a tertiary care hospital with a diagnosis of DKA over a four year period was performed. Paired bicarbonate values from a VBG and chemistry panel, if drawn within 60 minutes of each other, were compared. Results: At the time of diagnosis of DKA, 197 paired bicarbonate values were available for analysis with the mean difference between the two methods of testing of 2.5 mmol/L. 16 of the 197 (8%) paired values were discordant in meeting criteria for diagnosis of DKA. At the time of resolution of DKA, 83 paired bicarbonate samples were compared. The mean difference was 2.3 mmol/L. 20 of the 83 (24%) paired bicarbonate values showed discordance with regards to meeting the bicarbonate criteria for resolution of DKA. Conclusion: Discordance between bicarbonate results from different analysis methods may lead to different determinations as to whether or not a patient meets the biochemical definition for diagnosis and resolution of DKA.http://www.sciencedirect.com/science/article/pii/S2214623719300687
collection DOAJ
language English
format Article
sources DOAJ
author Poorani Nallam Goundan
Devina Luhur Willard
Ayse Sahin-Efe
Shu-Ling Liang Fan
Sara Michelle Alexanian
spellingShingle Poorani Nallam Goundan
Devina Luhur Willard
Ayse Sahin-Efe
Shu-Ling Liang Fan
Sara Michelle Alexanian
Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
Journal of Clinical & Translational Endocrinology
author_facet Poorani Nallam Goundan
Devina Luhur Willard
Ayse Sahin-Efe
Shu-Ling Liang Fan
Sara Michelle Alexanian
author_sort Poorani Nallam Goundan
title Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
title_short Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
title_full Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
title_fullStr Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
title_full_unstemmed Comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
title_sort comparison of bicarbonate values from venous blood gas and chemistry panels measured at the time of diagnosis and resolution of diabetes ketoacidosis
publisher Elsevier
series Journal of Clinical & Translational Endocrinology
issn 2214-6237
publishDate 2019-12-01
description Objective: To determine if bicarbonate values from venous blood gas (VBG) and plasma chemistry samples provided agreement in determining the bicarbonate criteria for the diagnosis and/or resolution of diabetic ketoacidosis (DKA). Methods: A retrospective chart review of data from patients admitted to a tertiary care hospital with a diagnosis of DKA over a four year period was performed. Paired bicarbonate values from a VBG and chemistry panel, if drawn within 60 minutes of each other, were compared. Results: At the time of diagnosis of DKA, 197 paired bicarbonate values were available for analysis with the mean difference between the two methods of testing of 2.5 mmol/L. 16 of the 197 (8%) paired values were discordant in meeting criteria for diagnosis of DKA. At the time of resolution of DKA, 83 paired bicarbonate samples were compared. The mean difference was 2.3 mmol/L. 20 of the 83 (24%) paired bicarbonate values showed discordance with regards to meeting the bicarbonate criteria for resolution of DKA. Conclusion: Discordance between bicarbonate results from different analysis methods may lead to different determinations as to whether or not a patient meets the biochemical definition for diagnosis and resolution of DKA.
url http://www.sciencedirect.com/science/article/pii/S2214623719300687
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