CLINICAL AND IMMUNO-METABOLIC PECULIARITIES OF THE PRIMARY ATTACK OF ACUTE LYMPHOBLASTIC LEUKEMIA

• Main Authors: Olga Valentinovna Smirnova, Valery Timofeevich Manchuk
• Format: Article
• Language: English
• Published: Science and Innovation Center Publishing House 2017-12-01
• Series: В мире научных открытий
• Subjects: острый лимфобластный лейкоз; первичная атака; лимфоцит; метаболизм; иммунитет
• Online Access: http://journal-s.org/index.php/vmno/article/view/10508

The authors studied the characteristics of the clinical condition, cellular, humoral immunity and metabolism of lymphocytes in patients with acute lymphoblastic leukemia at the onset of the disease, with the primary attack. The disease usually begins with the combined symptoms appearance in the clinical picture. Fever, fatigue, decreased performance, dizziness, the accompanying infection process were recorded in most patients. Reduction of T-lymphocytes and a decrease in the ratio of CD4+ to CD8+ contributed to the debut appearance of ALL and T-cell immunodeficiency development. Changed metabolomics of energy, plastic processes in lymphocytes. The authors proposed an immunometabolic own concept of the disease.