Relationship between ACR in patients with diabetic nephropathy and serum oxidative stress and angiogenesis indexes as well as peripheral blood T cell content

• Main Authors: Wei Xia, Wei-Yi Ni, Long Dai, Qing Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-02-01
• Series: Journal of Hainan Medical University
• Subjects: Diabetic nephropathy; Oxidative stress; Angiogenesis; T lymphocyte
• Online Access: http://www.hnykdxxb.com/PDF/201702/36.pdf

Objective: To study the correlation between urine albumin/creatinine ratio (ACR) in patients with diabetic nephropathy and the content of serum oxidative stress and angiogenesis indexes as well as peripheral blood T cells. Methods: Patients with type 2 diabetes were retrospectively analyzed, and patients with ＜3 mg/mmol, 3-30 mg/mmol and ＞30 mg/mmol were screened respectively as the DM1 group, DM2 group and DM3 group of the study; healthy volunteers were selected as control group. Serum was collected to determine oxidative stress and angiogenesis indexes, and peripheral blood was collected to determine the content of T cells. Results: Serum SOD, GSH-Px and CAT content as well as peripheral blood Th2 and Treg content of DM1 group, DM2 group and DM3 group were significantly lower than those of control group and the higher the ACR, the lower the serum SOD, GSH-Px and CAT content as well as peripheral blood Th2 and Treg content; serum MDA, 8-OHdG, VEGF, Ang1 and Ang2 content as well as peripheral blood Th1 and Th17 content were significantly higher than those of control group and the higher the ACR, the higher the serum MDA, 8-OHdG, VEGF, Ang1 and Ang2 content as well as peripheral blood Th1 and Th17 content. Conclusion: Enhanced oxidative stress, increased angiogenesis as well as T lymphocyte disorders are closely associated with the progression of diabetic nephropathy.