Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach

Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach

Prolonged B-cell depletion due to anti-CD20 monoclonal antibody (mAbs) therapy impairs the adaptive immune response, causing severe manifestations during COronaVIrus Disease-2019 (COVID-19). The cases of two patients under anti-CD20 therapy who experienced prolonged and severe COVID-19 successfully...

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Main Authors: Alessandra D’Abramo, Serena Vita, Gaetano Maffongelli, Andrea Mariano, Chiara Agrati, Concetta Castilletti, Delia Goletti, Giuseppe Ippolito, Emanuele Nicastri
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:International Journal of Infectious Diseases
Subjects:
Anti-CD20 therapy
SARS-CoV-2 infection
B-cell depletion
Prolonged infection
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971221003805
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spelling doaj-0b644ebc14794c0aa29f8e69ce507fcb2021-06-17T04:46:02ZengElsevierInternational Journal of Infectious Diseases1201-97122021-06-01107247250Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approachAlessandra D’Abramo0Serena Vita1Gaetano Maffongelli2Andrea Mariano3Chiara Agrati4Concetta Castilletti5Delia Goletti6Giuseppe Ippolito7Emanuele Nicastri8National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyCorresponding author.; National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyNational Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, via Portuense 292, 00149, Rome, ItalyProlonged B-cell depletion due to anti-CD20 monoclonal antibody (mAbs) therapy impairs the adaptive immune response, causing severe manifestations during COronaVIrus Disease-2019 (COVID-19). The cases of two patients under anti-CD20 therapy who experienced prolonged and severe COVID-19 successfully treated with mAbs against Severe Acute Respiratory Syndrome-CoV-2 spike proteins are reported.http://www.sciencedirect.com/science/article/pii/S1201971221003805Anti-CD20 therapySARS-CoV-2 infectionB-cell depletionProlonged infection
collection DOAJ
language English
format Article
sources DOAJ
author Alessandra D’Abramo
Serena Vita
Gaetano Maffongelli
Andrea Mariano
Chiara Agrati
Concetta Castilletti
Delia Goletti
Giuseppe Ippolito
Emanuele Nicastri
spellingShingle Alessandra D’Abramo
Serena Vita
Gaetano Maffongelli
Andrea Mariano
Chiara Agrati
Concetta Castilletti
Delia Goletti
Giuseppe Ippolito
Emanuele Nicastri
Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach
International Journal of Infectious Diseases
Anti-CD20 therapy
SARS-CoV-2 infection
B-cell depletion
Prolonged infection
author_facet Alessandra D’Abramo
Serena Vita
Gaetano Maffongelli
Andrea Mariano
Chiara Agrati
Concetta Castilletti
Delia Goletti
Giuseppe Ippolito
Emanuele Nicastri
author_sort Alessandra D’Abramo
title Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach
title_short Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach
title_full Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach
title_fullStr Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach
title_full_unstemmed Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach
title_sort prolonged and severe sars-cov-2 infection in patients under b-cell-depleting drug successfully treated: a tailored approach
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
publishDate 2021-06-01
description Prolonged B-cell depletion due to anti-CD20 monoclonal antibody (mAbs) therapy impairs the adaptive immune response, causing severe manifestations during COronaVIrus Disease-2019 (COVID-19). The cases of two patients under anti-CD20 therapy who experienced prolonged and severe COVID-19 successfully treated with mAbs against Severe Acute Respiratory Syndrome-CoV-2 spike proteins are reported.
topic Anti-CD20 therapy
SARS-CoV-2 infection
B-cell depletion
Prolonged infection
url http://www.sciencedirect.com/science/article/pii/S1201971221003805
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