High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916

High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916

<p>Abstract</p> <p>Background</p> <p>Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of predictive biomarkers to th...

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Bibliographic Details
Main Authors: Hardwicke Mary, Bachman Kurtis, Jing Junping, Greshock Joel, Plant Ramona, Oleykowski Catherine A, Moy Christopher, Wooster Richard, Degenhardt Yan
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/9/1/110

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